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Cholesterol-modified lignin: A new avenue for green nanoparticles, meltable materials, and drug delivery
Zhaleh Pourmoazzen1, Hasan Sadeghifar2, Guihua Yang3
1State Key Laboratory of Biobased Materials and Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences, Shandong Province, Jinan, 250353, PR China; Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695, USA; Department of Chemistry, North Carolina State University, Raleigh, NC, 27695, USA.
Abstract:
Two fractions of kraft lignin of low and high molecular weight were reacted with cholesteryl chloroformate (Chol.Cl) to produce a modified lignin that demonstrated very high hydrophobicity. Surprisingly, both fractions displayed discernible melting points as opposed to the starting lignin. The suspension in water also gave rise to nanoparticles that displayed sizes in the range of 200-500 nm that were shown to satisfactorily load and release folic acid, a representative hydrophobic molecule, within the context of drug delivery.
