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Reproducibility of heart rate changes following adenosine infusion in man
B Clarke1, T B Conradson, C M Dixon
1Department of Clinical Pharmacology, Cardiothoracic Institute, Brompton Hospital, London, UK.
European Journal of Clinical Pharmacology
|January 1, 1988
Abstract:
The change in heart rate following infusion of adenosine in healthy human subjects was studied on two occasions. Adenosine produced a significant, dose-related increase in heart rate. Tachyphylaxis to this effect of the naturally occurring nucleoside did not occur. There was a tendency for prolonged infusion to cause a greater increase in heart rate, but this did not reach significance.