Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

iPS Cell Differentiation01:22

iPS Cell Differentiation

3.0K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.0K
Epigenetic Regulation01:37

Epigenetic Regulation

3.7K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.7K
Epigenetic Regulation01:46

Epigenetic Regulation

33.3K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.3K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

3.2K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.2K
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

2.5K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.5K
Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

2.1K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Case study of resecabtagene autoleucel in a subject with diffuse cutaneous systemic sclerosis treated in the RESET-SSc trial.

Molecular therapy. Advances·2026
Same author

Endothelial cell-derived plasminogen activator inhibitor-1 potentiates thrombosis in antiphospholipid syndrome.

Journal of autoimmunity·2026
Same author

Nintedanib attenuates profibrotic gene expression in a 3-dimensional organotypic culture model of systemic sclerosis skin fibrosis.

The Journal of investigative dermatology·2026
Same author

A potent inhibitor of PAI-1, MDI-2517, mitigates disease severity in a preclinical systemic sclerosis model.

JCI insight·2026
Same author

Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis.

Annals of the rheumatic diseases·2026
Same author

Soluble CD13 in systemic sclerosis: clinical observations and transcriptomic insights from peripheral blood.

Arthritis research & therapy·2026

Related Experiment Video

Updated: Jan 2, 2026

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
08:09

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

8.5K

Epigenetic Control of Scleroderma: Current Knowledge and Future Perspectives.

Pei-Suen Tsou1

  • 1Division of Rheumatology, Department of Internal Medicine, University of Michigan, 109 Zina Pitcher Pl., 4025 BSRB, Ann Arbor, MI, 48109-2200, USA. ptsou@umich.edu.

Current Rheumatology Reports
|December 9, 2019
PubMed
Summary

Epigenetic mechanisms like DNA methylation and histone modifications are crucial in systemic sclerosis (SSc) pathogenesis. Understanding these epigenetic changes in SSc offers potential for new therapeutic strategies.

Keywords:
DNA methylationEpigeneticsHistone modificationsNon-coding RNAsScleroderma

More Related Videos

Author Spotlight: Advancements in Cell and Tissue Engineering for Tendon Repair
04:48

Author Spotlight: Advancements in Cell and Tissue Engineering for Tendon Repair

Published on: March 1, 2024

2.3K
Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis
09:16

Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis

Published on: December 14, 2015

11.8K

Related Experiment Videos

Last Updated: Jan 2, 2026

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
08:09

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

8.5K
Author Spotlight: Advancements in Cell and Tissue Engineering for Tendon Repair
04:48

Author Spotlight: Advancements in Cell and Tissue Engineering for Tendon Repair

Published on: March 1, 2024

2.3K
Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis
09:16

Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis

Published on: December 14, 2015

11.8K

Area of Science:

  • Molecular Biology
  • Immunology
  • Rheumatology

Background:

  • Systemic sclerosis (SSc) is a complex autoimmune disease characterized by fibrosis and vascular abnormalities.
  • Epigenetic modifications are increasingly recognized as key players in the development and progression of autoimmune disorders.

Purpose of the Study:

  • To review the role of three major epigenetic mechanisms in the pathogenesis of systemic sclerosis (SSc).
  • To discuss the involvement of DNA methylation, histone modifications, and non-coding RNAs in SSc development and progression.

Main Methods:

  • Review of current literature on epigenetic alterations in SSc.
  • Analysis of studies investigating DNA methylation, histone modifications, and non-coding RNAs in SSc pathogenesis.

Main Results:

  • Epigenetic alterations are observed in immune cells, dermal fibroblasts, and endothelial cells of SSc patients.
  • Affected genes are involved in immune function, TGFβ and Wnt pathways, extracellular matrix accumulation, and angiogenesis.
  • Current evidence suggests epigenetic changes are critical for SSc pathogenesis, though studies are pre-clinical.

Conclusions:

  • Epigenetic mechanisms significantly contribute to the pathogenesis and clinical heterogeneity of SSc.
  • Future epigenomic studies are essential for a deeper understanding of SSc.
  • Epigenetic insights may pave the way for repurposing epigenetic-modifying agents for SSc treatment.