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Cardiovascular Comorbidities in Psoriatic Disease
Agnes Szentpetery1, Muhammad Haroon2, Oliver FitzGerald3
1Department of Rheumatology, Uppsala University Hospital, Uppsala, Sweden.
Rheumatology and Therapy
|December 9, 2019
Summary
Psoriatic disease (PsD) patients have increased cardiovascular risk due to accelerated atherosclerosis. Managing PsD inflammation and traditional risk factors is crucial for preventing cardiovascular events.
Area of Science:
- Rheumatology and Cardiology
- Inflammatory Diseases
- Cardiovascular Health
Background:
- Psoriatic disease (PsD) is linked to a high prevalence of cardiovascular (CV) risk factors.
- PsD contributes to accelerated atherosclerosis, evidenced by imaging studies showing plaque formation and stenosis.
- Atherosclerosis in PsD is driven by frequent traditional risk factors and systemic inflammation.
Purpose of the Study:
- To highlight the connection between psoriatic disease and accelerated atherosclerosis.
- To emphasize the role of systemic inflammation and traditional risk factors in PsD-related CV complications.
- To underscore the importance of managing both PsD and CV risk factors.
Main Methods:
- Review of imaging studies (ultrasound, CT, PET) confirming atherosclerotic changes in PsD patients.
- Analysis of the interplay between traditional CV risk factors and systemic inflammation in PsD.
- Assessment of current best practices for managing CV risk in PsD.
Main Results:
- Imaging studies confirm significant atherosclerotic changes, including plaque and stenosis, in PsD.
- Both traditional risk factors and inflammatory processes contribute to atherosclerosis in PsD.
- Current best practice involves regular assessment, prevention, and treatment of CV risk factors alongside PsD management.
Conclusions:
- Accelerated atherosclerosis is a significant concern in psoriatic disease.
- Effective management requires addressing both traditional CV risk factors and underlying PsD inflammation.
- Further research is needed to elucidate mechanisms and develop targeted prevention/treatment strategies.
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