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The Metabolic Interplay between Cancer and Other Diseases

Anne Le1, Sunag Udupa2, Cissy Zhang3

  • 1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Trends in Cancer
|December 10, 2019
PubMed

Insights

Cancer metabolism is linked to systemic diseases like diabetes and aging. Understanding these connections reveals new therapeutic strategies for cancer treatment.

Area of Science:

  • Oncology
  • Metabolic research
  • Translational medicine

Background:

  • Cancer metabolism research has identified clinically relevant therapeutic targets.
  • Limited studies explore the metabolic processes shared between cancer and other diseases.
  • Significant metabolic overlap exists between cancer and conditions like diabetes, cardiovascular disease, neurological disorders, obesity, and aging.

Purpose of the Study:

  • To review the interconnectedness of cancer metabolism with systemic metabolism.
  • To highlight how insights from other diseases can inform novel cancer therapeutic strategies.

Main Methods:

  • Literature review of cancer metabolism.
  • Analysis of metabolic pathways shared across different diseases.
  • Examination of clinical trial data for metabolic therapies.

Main Results:

  • Cancer shares metabolic pathways with numerous non-cancerous diseases.
  • Therapeutic strategies targeting these shared pathways are emerging and entering clinical trials.
  • The interconnected metabolic network is crucial for understanding cancer.

Conclusions:

  • Considering the systemic metabolic context is essential for advancing cancer therapy.
  • Leveraging knowledge from diseases like diabetes and aging offers promising new avenues for cancer treatment.
Keywords:
agingcancer metabolismcardiovascular diseasesdiabetesneurological diseasesobesity

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