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Updated: Jan 2, 2026

Stimulation of Vascular Endothelial Cells Using Neutrophil Extracellular Traps in the Presence of Low-Density Lipoprotein
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Stimulation of Vascular Endothelial Cells Using Neutrophil Extracellular Traps in the Presence of Low-Density Lipoprotein

Published on: August 12, 2025

639

LDL as a therapeutic objective

Ángel Díaz Rodríguez1, Teresa Mantilla Morató2

  • 1Centro Salud de Bembibre, León, España.

Clinica E Investigacion En Arteriosclerosis : Publicacion Oficial De La Sociedad Espanola De Arteriosclerosis
|December 10, 2019
PubMed

Insights

Atherosclerotic cardiovascular disease is rising, with dyslipidemia as a key risk factor. New LDL-lowering treatments, including PCSK9 inhibitors, offer breakthroughs alongside cost-effective statins for prevention.

Area of Science:

  • Cardiology
  • Lipidology
  • Preventive Medicine

Background:

  • Increasing incidence of atherosclerotic cardiovascular disease (ASCVD) in developed nations.
  • Dyslipidemia, particularly elevated LDL cholesterol, is a major modifiable risk factor for ASCVD.
  • Effective LDL lowering is a primary therapeutic objective for ASCVD risk reduction.

Purpose of the Study:

  • To review current strategies for managing dyslipidemia to reduce cardiovascular risk.
  • To highlight the role of statins and newer therapies like PCSK9 inhibitors.
  • To emphasize the utility of the 2019 European Society of Cardiology/European Atherosclerosis Society guidelines in clinical practice.

Main Methods:

  • Review of current literature and clinical guidelines on dyslipidemia management.
  • Focus on lipid-modifying therapies, including statins and PCSK9 inhibitors.
  • Analysis of evidence and recommendations from the 2019 ESC/EAS guidelines.

Main Results:

  • Statins remain a cost-effective option for primary and secondary ASCVD prevention.
  • PCSK9 inhibitors represent a significant advancement, offering potent LDL reduction.
  • Personalized treatment goals are crucial for optimal patient outcomes.

Conclusions:

  • The 2019 ESC/EAS guidelines provide a framework for evidence-based dyslipidemia management.
  • A combination of established and novel therapies can effectively reduce cardiovascular risk.
  • Tailoring lipid-modifying strategies to individual patient needs is essential for clinical success.

Keywords:
Cardiovascular diseaseColesterol LDLEnfermedad cardiovascularEstatinas, Inhibidores PSCK9LDL cholesterolObjetivos tratamientoPSCK9 inhibitorsStatinsTreatment targets

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