Difference in the prevalence of subclinical left ventricular impairment among left ventricular geometric pattern in a

Takuya Hasegawa1, Masanori Asakura2, Hiroshi Asanuma2

  • 1Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.

Journal of Cardiology
|December 10, 2019
PubMed

Insights

Left ventricular (LV) hypertrophy increases the risk of LV diastolic dysfunction. Even without apparent geometric changes, subclinical diastolic dysfunction is prevalent in the general population, highlighting the need for further research.

Area of Science:

  • Cardiology
  • Echocardiography
  • Public Health

Background:

  • Left ventricular (LV) hypertrophy is a known precursor to LV diastolic dysfunction.
  • Understanding the prevalence of diastolic dysfunction across different LV hypertrophy patterns is crucial for cardiovascular health assessment.

Purpose of the Study:

  • To determine the prevalence of LV diastolic dysfunction in a community-based population.
  • To analyze the relationship between LV geometric patterns and LV diastolic dysfunction.

Main Methods:

  • A community-based study of 1260 asymptomatic individuals was conducted.
  • Subjects were categorized into four LV geometric patterns: normal, concentric remodeling, eccentric hypertrophy, and concentric hypertrophy.
  • LV diastolic function was assessed using three echocardiographic parameters, with dysfunction defined by abnormalities in at least two.

Main Results:

  • LV diastolic dysfunction prevalence increased with the severity of LV hypertrophy.
  • LV mass index, not relative wall thickness, was a significant predictor of diastolic dysfunction, even after accounting for comorbidities.
  • Notably, 10% of subjects with normal LV geometry exhibited subclinical LV diastolic dysfunction.

Conclusions:

  • The prevalence of LV diastolic dysfunction is higher in individuals with more severe LV hypertrophy within a community setting.
  • Subclinical LV diastolic dysfunction, occurring without obvious geometric changes, warrants attention and further investigation into its clinical significance.
Abstract

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