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Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
Published on: October 28, 2020
Difference in the prevalence of subclinical left ventricular impairment among left ventricular geometric pattern in a
Takuya Hasegawa1, Masanori Asakura2, Hiroshi Asanuma2
1Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.
Insights
Left ventricular (LV) hypertrophy increases the risk of LV diastolic dysfunction. Even without apparent geometric changes, subclinical diastolic dysfunction is prevalent in the general population, highlighting the need for further research.
Area of Science:
- Cardiology
- Echocardiography
- Public Health
Background:
- Left ventricular (LV) hypertrophy is a known precursor to LV diastolic dysfunction.
- Understanding the prevalence of diastolic dysfunction across different LV hypertrophy patterns is crucial for cardiovascular health assessment.
Purpose of the Study:
- To determine the prevalence of LV diastolic dysfunction in a community-based population.
- To analyze the relationship between LV geometric patterns and LV diastolic dysfunction.
Main Methods:
- A community-based study of 1260 asymptomatic individuals was conducted.
- Subjects were categorized into four LV geometric patterns: normal, concentric remodeling, eccentric hypertrophy, and concentric hypertrophy.
- LV diastolic function was assessed using three echocardiographic parameters, with dysfunction defined by abnormalities in at least two.
Main Results:
- LV diastolic dysfunction prevalence increased with the severity of LV hypertrophy.
- LV mass index, not relative wall thickness, was a significant predictor of diastolic dysfunction, even after accounting for comorbidities.
- Notably, 10% of subjects with normal LV geometry exhibited subclinical LV diastolic dysfunction.
Conclusions:
- The prevalence of LV diastolic dysfunction is higher in individuals with more severe LV hypertrophy within a community setting.
- Subclinical LV diastolic dysfunction, occurring without obvious geometric changes, warrants attention and further investigation into its clinical significance.
Background:
Left ventricular (LV) hypertrophy is reported to cause LV diastolic dysfunction. This study aimed to examine the prevalence of LV diastolic dysfunction in each group categorized by the geometric pattern of LV hypertrophy in a community-based population.
Methods:
We studied 1260 community-dwelling subjects who experienced no symptoms of obvious heart disease (461 men, 799 women) and who participated in annual health check-ups in a rural Japanese community. The subjects were divided into 4 groups according to LV mass index and relative wall thickness: normal geometry, concentric remodeling, eccentric hypertrophy, and concentric hypertrophy. We investigated the prevalence of LV diastolic dysfunction in the overall and stratified population by LV geometric pattern. LV diastolic function was determined by 3 echocardiographic parameters of LV diastolic function: early diastolic myocardial velocity, the ratio of early diastolic mitral inflow velocity and myocardial velocity, and indexed left atrial dimension. LV diastolic dysfunction was defined as the presence of abnormal values in more than 2 of 3 echocardiographic parameters.
Results:
The prevalence of LV diastolic dysfunction was higher in the categories with more severe LV hypertrophy. However, LV mass index, rather than relative wall thickness, was a significant determinant of LV diastolic dysfunction, after adjustment for comorbidities. In addition, 71 (10%) out of 740 subjects with normal LV geometric pattern had LV diastolic dysfunction even without obvious LV geometric change.
Conclusions:
The prevalence of LV diastolic dysfunction was higher in the subjects with more severe LV hypertrophy in a community-based population. Subclinical LV diastolic dysfunction without obvious LV geometric change should be noted and its clinical impact should be elucidated.
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