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Corticosteroid effects on cholinergic enzymes in ethanol-treated fetal brain cell cultures
J W Brown1, A D Okonmah, K F Soliman
1Medical Research Service, Veterans Administration Medical Center, Miami, Florida.
Experientia
|October 15, 1988
Abstract:
In the presence of ethanol, corticosterone and dexamethasone inhibit choline acetyltransferase and acetyl-cholinesterase activities in cultured fetal brain cells of the rat. These results suggest that corticosteroids may have an important influence on the activity of cholinergic enzymes in the fetal brain may antagonize the effects of ethanol in this setting.