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T Cell Antifungal Immunity and the Role of C-Type Lectin Receptors

Emily A Speakman1, Ivy M Dambuza1, Fabián Salazar1

  • 1Medical Research Council (MRC) Centre for Medical Mycology, University of Exeter, Exeter EX4 4QD, UK.

Trends in Immunology
|December 10, 2019
PubMed

Insights

C-type lectin receptors (CLRs) are crucial for antifungal immunity, initiating innate responses and shaping adaptive immunity. These receptors also regulate T cell responses and maintain homeostasis against fungal pathogens.

Area of Science:

  • Immunology
  • Mycology

Background:

  • Fungal infections pose significant health risks, ranging from superficial to systemic diseases.
  • Antifungal immunity relies on pattern recognition receptors (PRRs), notably C-type lectin receptors (CLRs), for pathogen recognition.

Purpose of the Study:

  • To provide an overview of current knowledge on T cell-mediated antifungal immune responses.
  • To emphasize the critical role of C-type lectins in modulating these responses.

Main Methods:

  • Review of existing literature on CLRs and antifungal immunity.
  • Analysis of CLR interactions with innate and adaptive immune cells.

Main Results:

  • CLRs initiate innate antifungal responses like phagocytosis and fungal killing.
  • CLRs influence T cell function and adaptive immunity development.
  • CLR-mediated recognition of commensal fungi is vital for immune homeostasis.

Conclusions:

  • C-type lectin receptors are central regulators of antifungal immunity.
  • Understanding CLR function offers potential therapeutic strategies against fungal infections.
Keywords:
C-type lectin receptorsadaptive T cell immunityantifungal immunityfungal pathogensmycobiome

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