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Inter-Arm Blood Pressure Difference in Diabetes Mellitus and Its Preferential Association with Peripheral Artery

Masako Miyashima1, Tetsuo Shoji2,3, Yoshinori Kakutani1

  • 1Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine.

Journal of Atherosclerosis and Thrombosis
|December 10, 2019
PubMed

Insights

Diabetes does not independently increase inter-arm blood pressure difference (IAD). A larger IAD is linked to peripheral artery disease (PAD), especially in younger individuals, highlighting PAD as a key association.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Diabetes Research

Background:

  • Inter-arm blood pressure difference (IAD) is linked to cardiovascular disease (CVD) and risk factors.
  • Limited data exists on diabetes mellitus's role in IAD and its association with specific CVDs like coronary artery disease (CAD), stroke, and peripheral artery disease (PAD).

Purpose of the Study:

  • To investigate the contribution of diabetes mellitus to IAD.
  • To examine the association between IAD and individual CVDs (CAD, stroke, PAD).

Main Methods:

  • Cross-sectional study involving 2580 participants.
  • Simultaneous, automated blood pressure measurements in both arms were taken.
  • Analysis included comparisons between diabetic and non-diabetic groups and associations with specific CVDs.

Main Results:

  • Diabetic patients showed a greater IAD and higher prevalence of IAD ≥ 10 mmHg compared to non-diabetic subjects, but this was not significant after confounder adjustment.
  • Peripheral artery disease (PAD) was the only CVD significantly associated with IAD after adjusting for risk factors.
  • Age modified the IAD-PAD association, being stronger in younger individuals.

Conclusions:

  • Diabetes mellitus is not an independent predictor of IAD.
  • A larger IAD is primarily associated with PAD, with a notable age-dependent effect.
  • IAD assessment may aid in identifying PAD, particularly in younger patients.
Abstract

Keywords:
Blood pressureCardiovascular diseaseDiabetes mellitusInter-arm blood pressure difference

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