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Commentary: Reliability of the New AOSpine Classification System for Upper Cervical Traumatic Injuries

Anastasios Charalampidis1,2, Michael G Fehlings3,4

  • 1Department of Clinical Sciences, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.

Neurosurgery
|December 10, 2019
PubMed
Abstract

No abstract available in PubMed .

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Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
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