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Management of immune checkpoint inhibitor-related dermatologic adverse events

Xiaoyan Si1, Chunxia He2, Li Zhang3

  • 1Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Beijing, China.

Thoracic Cancer
|December 10, 2019
PubMed

Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. The unique spectrum of immune-related adverse events (IrAEs) may occur during treatment. Dermatologic toxicities appear to be one of the most prevalent immunotherapy-related adverse events. The most common symptoms are maculopapular rash and pruritus. Serious dermatologic toxicities including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reactions with eosinophilia and systemic symptoms are rare. In this review, we summarize guidelines of management of immunotherapy-related toxicities, case reports, and proposed treatment recommendation.

Keywords:
Dermatologic toxicitiesimmune checkpoint inhibitor (ICI)immune-related adverse events (IrAEs)

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