Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Artificial Intelligence Driven Adjusted OCT-Based Classification System for Diabetic Macular Edema (AIDME).

Clinical ophthalmology (Auckland, N.Z.)·2026
Same author

Validation of artificial intelligence algorithm LuxIA for screening of diabetic retinopathy from a single 45° retinal colour fundus images: the CARDS study.

BMJ open ophthalmology·2025
Same author

Development of LuxIA, a Cloud-Based AI Diabetic Retinopathy Screening Tool Using a Single Color Fundus Image.

Translational vision science & technology·2023
Same author

Microperimetry in hydroxychloroquine macular toxicity.

Romanian journal of ophthalmology·2022
Same author

Does real-time artificial intelligence-based visual pathology enhancement of three-dimensional optical coherence tomography scans optimise treatment decision in patients with nAMD? Rationale and design of the RAZORBILL study.

The British journal of ophthalmology·2021
Same author

Response to: Comments to: Management of diabetic macular edema patients in clinical practice in Spain.

European journal of ophthalmology·2020

Related Experiment Video

Updated: Jan 2, 2026

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
07:18

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography

Published on: February 18, 2022

2.1K

Structure-Function Correlation Using OCT Angiography And Microperimetry In Diabetic Retinopathy.

Marta Alonso-Plasencia1, Rodrigo Abreu-González1, Mario Alberto Gómez-Culebras2

  • 1Ophthalmology Department, University Hospital of Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.

Clinical Ophthalmology (Auckland, N.Z.)
|December 10, 2019
PubMed
Summary

Diabetic retinopathy (DR) without macular edema reduces retinal vessel density (VD) and retinal sensitivity (RS). Microangiopathic changes correlate with sensitivity loss in specific areas, particularly temporal to the fovea.

Keywords:
diabetic retinopathyretinal sensitivityvessel density

More Related Videos

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
07:23

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

8.6K
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

3.3K

Related Experiment Videos

Last Updated: Jan 2, 2026

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
07:18

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography

Published on: February 18, 2022

2.1K
Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
07:23

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

8.6K
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

3.3K

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Diabetology

Background:

  • Diabetic retinopathy (DR) is a leading cause of vision loss.
  • Assessing structural and functional changes in DR is crucial for management.
  • Optical coherence tomography angiography (OCTA) allows non-invasive visualization of retinal vasculature.

Purpose of the Study:

  • To evaluate macular vasculature in diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA).
  • To correlate vessel density (VD) with retinal sensitivity (RS) in DR patients.
  • To assess structural and functional changes in DR without clinically significant diabetic macular edema (DME).

Main Methods:

  • Prospective observational cross-sectional study.
  • Inclusion of diabetic patients with DR (no DME) and healthy controls.
  • OCTA for macular vessel density measurement and microperimetry for retinal sensitivity assessment in 9 areas.

Main Results:

  • Reduced mean retinal sensitivity (RS) and vessel density (VD) in the DR group compared to controls (p<0.05).
  • VD was decreased in 7 of 9 areas in the DR group.
  • A moderate correlation between VD and RS was found in the area temporal to the fovea in the DR group (r=0.501, p=0.01).

Conclusions:

  • Diabetic retinopathy without DME leads to decreased retinal vessel density, potentially causing reduced retinal sensitivity.
  • Microangiopathic changes in DR correlate with microperimetry sensitivity drop, particularly in the temporal foveal region.
  • OCTA and microperimetry are valuable tools for assessing structural and functional deficits in DR.