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Updated: Jan 2, 2026
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Ex Vivo Organotypic Corneal Model of Acute Epithelial Herpes Simplex Virus Type I Infection
Published on: November 3, 2012
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Clinical Pattern And Visual Impairment Associated With Herpes Simplex Keratitis.
Anica Shah1, Purushottam Joshi1, Bijaya Bhusal1
1Department of Cornea, Mechi Eye Hospital, Birtamode, Nepal.
Clinical Ophthalmology (Auckland, N.Z.)
|December 10, 2019
Summary
Herpes simplex keratitis (HSK) commonly causes vision loss, with stromal keratitis without ulceration being the most frequent presentation in Nepal. This study highlights HSK
Area of Science:
- Ophthalmology
- Infectious Diseases
- Public Health
Background:
- Herpes simplex keratitis (HSK) is a leading cause of corneal scarring and visual impairment globally.
- Understanding HSK presentation patterns is crucial for effective management and prevention of vision loss.
Purpose of the Study:
- To determine the incidence and clinical patterns of HSK at a tertiary eye care center in eastern Nepal.
- To assess the visual impairment associated with HSK presentations.
Main Methods:
- A descriptive, cross-sectional study was conducted over one year.
- Included 302 clinically diagnosed cases of HSK.
- Detailed ocular examinations and visual acuity assessments were performed.
Main Results:
- Stromal keratitis without ulceration was the most common presentation (156 cases).
- Epithelial keratitis, stromal keratitis with ulceration, endothelitis, and neurotrophic ulcers were also observed.
- Significant visual impairment (<3/60) was noted in 35.7% at presentation and persisted in some patients upon follow-up.
Conclusions:
- HSK exhibits diverse clinical presentations and can lead to substantial vision impairment.
- Stromal keratitis without ulceration is a prevalent form of HSK in this region.
- Further long-term studies are needed to understand the full burden of visual morbidity due to recurrent HSK, especially in developing nations.
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