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LncRNA PTCSC3 suppressed cervical carcinoma cell invasion and proliferation via regulating miR-574-5p

Min Zhang1, Yinghui Song1, Lijuan Yu1

  • 1Gynecological Clinic, Cangzhou Central Hospital Cangzhou 061001, Hebei, China.

American Journal of Translational Research
|December 10, 2019
PubMed

Insights

Long non-coding RNA PTCSC3 acts as a tumor suppressor in cervical carcinoma by downregulating miR-574-5p. PTCSC3 overexpression inhibits cancer cell proliferation and invasion, suggesting its therapeutic potential.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Long non-coding RNAs (lncRNAs) are implicated in cancer development.
  • The role of PTCSC3 in cervical carcinoma progression is not well understood.

Purpose of the Study:

  • To investigate the function and mechanism of PTCSC3 in cervical carcinoma.
  • To determine the relationship between PTCSC3, miR-574-5p, and cervical carcinoma progression.

Main Methods:

  • Compared PTCSC3 and miR-574-5p expression in cervical carcinoma cell lines and tissues.
  • Overexpressed PTCSC3 in cervical carcinoma cells (Hela and Siha).
  • Assessed the effects of PTCSC3 overexpression on cell proliferation and invasion.

Main Results:

  • PTCSC3 expression was downregulated, while miR-574-5p was overexpressed in cervical carcinoma.
  • PTCSC3 overexpression inhibited miR-574-5p and enhanced SCAI expression.
  • PTCSC3 overexpression reduced cell proliferation and invasion.
  • PTCSC3 and miR-574-5p showed negative correlation in cervical carcinoma.

Conclusions:

  • PTCSC3 functions as a tumor suppressor in cervical carcinoma.
  • PTCSC3 suppresses cervical carcinoma progression by regulating miR-574-5p.
  • PTCSC3 may serve as a potential therapeutic target for cervical carcinoma.
Keywords:
Cervical carcinomaPTCSC3lncRNAmiR-574-5p

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