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Gram-negative bloodstream infections and sepsis: risk factors, screening tools and surveillance
Eleanor Mitchell1, Mark S Pearce1, Anthony Roberts1,2,3,4
1Population Health Sciences Institute, Newcastle University, UK.
Introduction And Background:
Incidence of gram-negative bloodstream infections (GNBSIs) and sepsis are rising in the UK. Healthcare-associated risk factors have been identified that increase the risk of infection and associated mortality. Current research is focused on identifying high-risk patients and improving the methods used for surveillance.
Sources Of Data:
Comprehensive literature search of the topic area using PubMed (Medline). Government, professional and societal publications were also reviewed.
Areas Of Agreement:
A range of healthcare-associated risk factors independently associate with the risk of GNBSIs and sepsis.
Areas Of Controversy:
There are calls to move away from using simple comorbidity scores to predict the risk of sepsis-associated mortality, instead more advanced multimorbidity models should be considered.
Growing Points And Areas For Developing Research:
Advanced risk models should be created and evaluated for their ability to predict sepsis-associated mortality. Investigations into the accuracy of NEWS2 to predict sepsis-associated mortality are required.
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