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Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications

Ju-Ha Kim1, Jisung Hwang1, Ji Hoon Jung1

  • 1Cancer Molecular Target Herbal Research Lab, College of Korean Medicine, Kyung Hee university, 1 Hoegi-dong, Dongdaemun-gu, Seoul, 02447, Republic of Korea.

Molecular Cancer
|December 10, 2019
PubMed

Insights

Forkhead box P (FOXP) proteins have dual roles in cancer, acting as oncogenes or tumor suppressors. This review clarifies FOXP3

Area of Science:

  • Molecular Biology
  • Immunology
  • Oncology

Background:

  • Forkhead box P (FOXP) transcription factors (FOXP1-4) are implicated in embryonic development, immune disorders, and cancer.
  • The specific function of FOXP3 in CD4+CD25+ regulatory T (Treg) cells and the oncogenic or tumor-suppressive roles of FOXP proteins in cancer remain controversial.

Purpose of the Study:

  • To review the historical research on FOXP proteins in cancer.
  • To elucidate the dual roles of FOXP proteins as oncogenes or tumor suppressors.
  • To explore their molecular interactions and clinical significance in cancer progression.

Main Methods:

  • Literature review of research on FOXP transcription factors.
  • Analysis of molecular networks involving FOXP proteins, other proteins, and noncoding RNAs.
  • Examination of cellular immunotherapy targeting FOXP3.
  • Review of clinical implications in cancer.

Main Results:

  • FOXP proteins exhibit context-dependent functions, acting as either oncogenes or tumor suppressors in various cancers.
  • FOXP3 plays a critical role in regulating CD4+CD25+ Treg cells, influencing the tumor microenvironment.
  • Complex molecular networks involving FOXP proteins and noncoding RNAs modulate their functions.

Conclusions:

  • Understanding the dual roles of FOXP proteins is crucial for cancer research and therapy.
  • Targeting FOXP3 in cellular immunotherapy presents potential clinical applications for cancer treatment.
  • Further research into FOXP protein networks can reveal novel therapeutic strategies for cancer progression.
Keywords:
Cellular immunotherapyClinical implications and cancer progressionFOXP proteinsMolecular networksNoncoding RNAs

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