Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

4.7K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.7K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

4.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Open-Label 9-Year Follow-Up Extension Phase 2 Study of Once-Weekly Somatrogon in Children With Growth Hormone Deficiency.

The Journal of clinical endocrinology and metabolism·2026
Same author

Psychotic Features in Myhre Syndrome: Evidence for Broader Neuropsychiatric Surveillance.

American journal of medical genetics. Part C, Seminars in medical genetics·2026
Same author

The Hidden Architecture of Brain Structural Variability in 22q11.2 Deletion Syndrome: A Multi-site Study.

medRxiv : the preprint server for health sciences·2026
Same author

Quantifying the Effect of Fat and Protein on the Postprandial Glucose Excursion in Individuals With Type 1 Diabetes Using an Automated Insulin Delivery System.

Journal of diabetes science and technology·2026
Same author

Atypical inter-brain synchrony and social communication deficits in girls with fragile X syndrome: Evidence from functional near-infrared spectroscopy hyperscanning.

European child & adolescent psychiatry·2026
Same author

Pediatric thyroid cancer lung metastases and RAI: long-term results.

Journal of pediatric endocrinology & metabolism : JPEM·2026

Related Experiment Video

Updated: Jan 2, 2026

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

6.6K

Executive task-based brain function in children with type 1 diabetes: An observational study.

Lara C Foland-Ross1, Bruce Buckingam2, Nelly Mauras3

  • 1Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, United States of America.

Plos Medicine
|December 10, 2019
PubMed
Summary

Children with type 1 diabetes (T1D) show altered brain activity in executive control regions and the default mode network (DMN). This increased brain activity in T1D may compensate for cognitive challenges, maintaining performance levels comparable to healthy peers.

More Related Videos

Event-related Potentials During Target-response Tasks to Study Cognitive Processes of Upper Limb Use in Children with Unilateral Cerebral Palsy
08:26

Event-related Potentials During Target-response Tasks to Study Cognitive Processes of Upper Limb Use in Children with Unilateral Cerebral Palsy

Published on: January 11, 2016

12.5K
Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

2.0K

Related Experiment Videos

Last Updated: Jan 2, 2026

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

6.6K
Event-related Potentials During Target-response Tasks to Study Cognitive Processes of Upper Limb Use in Children with Unilateral Cerebral Palsy
08:26

Event-related Potentials During Target-response Tasks to Study Cognitive Processes of Upper Limb Use in Children with Unilateral Cerebral Palsy

Published on: January 11, 2016

12.5K
Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

2.0K

Area of Science:

  • Neuroscience
  • Pediatric Endocrinology
  • Cognitive Science

Background:

  • Optimal glycemic control is challenging in pediatric type 1 diabetes (T1D).
  • The impact of dysglycemia on the developing brain in children with T1D is not well understood.
  • Executive functions and default mode network (DMN) activity are crucial for cognitive performance.

Purpose of the Study:

  • To investigate functional magnetic resonance imaging (fMRI) activation patterns during an executive function task in children with T1D compared to controls.
  • To explore the relationship between brain activation patterns, cognitive performance, and clinical disease course in pediatric T1D.
  • To understand how the brain adapts to T1D during development.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to assess brain activation in 93 children with T1D and 57 controls during a go/no-go executive function task.
  • Cognitive and clinical assessments were performed across five study sites.
  • Group differences in brain activation were analyzed, controlling for age, sex, and scan site.

Main Results:

  • Children with T1D exhibited increased activation in executive control regions (e.g., prefrontal cortex) and reduced suppression in the posterior DMN compared to controls, despite equivalent task performance.
  • Greater executive control region hyperactivation in T1D was associated with improved task performance (faster response times) and better parent-reported executive functioning.
  • Deficits in DMN deactivation in T1D were correlated with an earlier age of T1D onset.
  • Exploratory analyses revealed a positive association between DMN deactivation deficits and executive control region hyperactivation in the T1D group.

Conclusions:

  • Increased recruitment of executive control areas in pediatric T1D may compensate for DMN-related impairments.
  • These compensatory brain patterns facilitate cognitive and behavioral performance levels comparable to non-diabetic children.
  • Future research should investigate the effects of improved glycemic control on these observed brain activation patterns.