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Toxicities associated with checkpoint inhibitors-an overview

Laura Spiers1, Nicholas Coupe1, Miranda Payne1

  • 1Department of Oncology, Churchill Hospital, Oxford University Hospitals Foundation Trust, Oxford, UK.

Rheumatology (Oxford, England)
|December 10, 2019
PubMed

Immunotherapy has an increasing role in the management of cancer, both in metastatic disease and as an adjuvant therapy. However, sensitization of the immune system with checkpoint inhibitors comes with a unique side effect profile. Full appreciation of this can take some time to emerge as some adverse events are rare, or can be subtle and potentially overlooked. Clinician awareness of these side effects can be particularly important in patients with pre-existing autoimmune conditions. Here we describe common symptoms and diagnostic strategies for organ-specific side effects of anti-CTLA-4 and anti-PD-1/PD-L1 immunotherapy agents.

Keywords:
adverse eventcheckpoint inhibitor

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