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Published on: December 1, 2016
siRNA Conjugated Nanoparticles-A Next Generation Strategy to Treat Lung Cancer
Rasha Itani1, Achraf Al Faraj1
1Department of Radiologic Sciences, Faculty of Health Sciences, American University of Science and Technology (AUST), Beirut, Lebanon.
Abstract:
Despite major progress in both therapeutic and diagnostic techniques, lung cancer is still considered the leading cause of cancer mortality in the world due to the ineffectiveness of the classical treatments used nowadays. Luckily, the discovery of small interfering RNA (siRNA) planted hope in the hearts of scientists and patients worldwide as a new breakthrough in the world of oncology and a robust tool for finally curing cancer. However, the valuable siRNA must be protected and preserved to ensure the effectiveness of this gene therapy, thus nanoparticles are gaining more attention than previous years as the optimal carriers for this fragile molecule. siRNA-loaded nanoparticles are being extensively investigated to find the appropriate formulation, combination, and delivery route with one objective in mind-successfully overcoming all possible limitations shown in clinical studies and making full use of this novel technique to become the next generation treatment to wipe out many chronic diseases, including cancer. In this review, the benefits of using siRNA and nanoparticles in lung cancer treatment will be globally reviewed before discussing why and how nanoparticles and siRNA can be combined to achieve an efficient treatment of lung cancer for prospective clinical applications.
Insights
Small interfering RNA (siRNA) shows promise for lung cancer treatment. Nanoparticles effectively deliver siRNA, overcoming limitations for potential clinical applications in oncology.
Area of Science:
- Biomedical Engineering
- Oncology
- Molecular Biology
Background:
- Lung cancer remains a leading cause of cancer mortality globally.
- Current treatments for lung cancer have limitations in effectiveness.
- Small interfering RNA (siRNA) offers a novel therapeutic approach for cancer treatment.
Purpose of the Study:
- To review the benefits of using siRNA in lung cancer treatment.
- To discuss the role of nanoparticles as carriers for siRNA.
- To explore the combination of siRNA and nanoparticles for efficient lung cancer therapy.
Main Methods:
- Review of current literature on siRNA and nanoparticle applications in lung cancer.
- Analysis of the advantages and challenges of siRNA delivery systems.
- Exploration of formulation, combination, and delivery routes for siRNA-loaded nanoparticles.
Main Results:
- Nanoparticles are optimal carriers for protecting fragile siRNA molecules.
- siRNA-loaded nanoparticles are under extensive investigation for lung cancer treatment.
- Overcoming clinical limitations is key to realizing the potential of this gene therapy.
Conclusions:
- Combining siRNA with nanoparticles presents a promising strategy for effective lung cancer treatment.
- This approach aims to overcome existing therapeutic limitations and improve patient outcomes.
- Further research into formulation and delivery is crucial for prospective clinical applications.
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