Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The hidden IVUS effect: a meta-epidemiological analysis of control-arm optimization and treatment-effect attenuation in contemporary IVUS-guided PCI trials.

European heart journal open·2026
Same author

Resolving the dilution paradox to improve the interpretation of extracellular vesicle biomarker studies.

Research and practice in thrombosis and haemostasis·2026
Same author

Conduction system pacing in TAVR patients requiring permanent pacemaker implantation.

Heart rhythm·2026
Same author

From photoshop to artificial intelligence. Scientific integrity in the modern era of cardiovascular research: a call for action.

Journal of cardiovascular medicine (Hagerstown, Md.)·2026
Same author

Strategies and Timing of Complete Revascularization in STEMI Patients with Multivessel Coronary Artery Disease.

Journal of clinical medicine·2026
Same author

Diagnostic and Prognostic Value of Epigenetic Markers in Neurological Diseases. A Narrative Review.

Cellular and molecular neurobiology·2026

Related Experiment Video

Updated: Jan 2, 2026

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo
07:56

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

Published on: August 28, 2014

12.7K

Bioresorbable Vascular Scaffolds-Dead End or Still a Rough Diamond?

Mateusz P Jeżewski1, Michał J Kubisa1, Ceren Eyileten1

  • 1Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology, Medical University of Warsaw, 02091 Warsaw, Poland.

Journal of Clinical Medicine
|December 11, 2019
PubMed
Summary

Bioresorbable vascular scaffolds (BVS) initially aimed to improve upon drug-eluting stents (DES) but faced challenges. Current research explores their potential in specific patient groups despite earlier concerns.

Keywords:
acute coronary syndromeangioplastybioresorbable vascular scaffolddrug-eluting stentpercutaneous coronary intervention

More Related Videos

Nondestructive Monitoring of Degradable Scaffold-Based Tissue-Engineered Blood Vessel Development Using Optical Coherence Tomography
11:12

Nondestructive Monitoring of Degradable Scaffold-Based Tissue-Engineered Blood Vessel Development Using Optical Coherence Tomography

Published on: October 3, 2018

5.9K
A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch
07:51

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch

Published on: December 10, 2020

6.0K

Related Experiment Videos

Last Updated: Jan 2, 2026

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo
07:56

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

Published on: August 28, 2014

12.7K
Nondestructive Monitoring of Degradable Scaffold-Based Tissue-Engineered Blood Vessel Development Using Optical Coherence Tomography
11:12

Nondestructive Monitoring of Degradable Scaffold-Based Tissue-Engineered Blood Vessel Development Using Optical Coherence Tomography

Published on: October 3, 2018

5.9K
A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch
07:51

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch

Published on: December 10, 2020

6.0K

Area of Science:

  • Cardiovascular Medicine
  • Biomaterials Science
  • Interventional Cardiology

Background:

  • Percutaneous coronary interventions (PCI) using stent-based methods are standard for acute coronary syndromes.
  • Bioresorbable vascular scaffolds (BVS) were developed to offer drug-eluting stent (DES) efficacy with eventual disappearance, aiming to restore natural vessel function and reduce thrombosis.
  • Early promising results for BVS have been tempered by concerns regarding lower radial strength and increased thrombotic events compared to DES.

Purpose of the Study:

  • To review first and second-generation BVS technologies.
  • To summarize clinical trial outcomes for BVS.
  • To discuss reasons for suboptimal performance, potential improvements, and specific indications for BVS use.

Main Methods:

  • Review of clinical trial data and literature on first and second-generation Bioresorbable Vascular Scaffolds (BVS).
  • Analysis of factors contributing to adverse events associated with BVS.
  • Exploration of potential enhancements and niche applications for BVS.

Main Results:

  • While initially showing promise, BVS have demonstrated concerns including lower radial strength and higher thrombosis rates compared to drug-eluting stents (DES).
  • Despite advancements in second-generation BVS, they have not definitively surpassed DES in all applications.
  • Unfavorable outcomes have been linked to device properties and procedural factors.

Conclusions:

  • Bioresorbable vascular scaffolds (BVS) present a complex profile, with initial advantages overshadowed by safety concerns like thrombosis.
  • Further research and development are needed to optimize BVS performance and address limitations.
  • BVS may still hold potential for specific patient populations or indications where their unique properties offer distinct benefits over traditional DES.