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Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

1.4K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
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Overview of Synapses01:25

Overview of Synapses

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A synapse is a specialized structure where two neurons connect, allowing them to pass an electrical or chemical signal to another neuron. It is the point of communication between neurons. The term "synapse" is derived from the Greek word "synapsis," which means "conjunction." The entire process of neural communication revolves around the synapse. When activated, a neuron releases chemicals known as neurotransmitters into the synapse. These neurotransmitters cross the synapse and bind to...
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Integration of Synaptic Events01:28

Integration of Synaptic Events

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Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
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Plasticity00:58

Plasticity

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Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
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Long-term Potentiation01:25

Long-term Potentiation

3.3K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
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Long-term Potentiation01:35

Long-term Potentiation

58.0K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Related Experiment Video

Updated: Jan 2, 2026

Electrophysiological and Morphological Characterization of Neuronal Microcircuits in Acute Brain Slices Using Paired Patch-Clamp Recordings
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Electrophysiological and Morphological Characterization of Neuronal Microcircuits in Acute Brain Slices Using Paired Patch-Clamp Recordings

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Synaptic Plasticity Shapes Brain Connectivity: Implications for Network Topology.

Mario Stampanoni Bassi1, Ennio Iezzi1, Luana Gilio1

  • 1Unit of Neurology & Neurorehabilitation, IRCCS Neuromed, 86077 Pozzilli, Italy.

International Journal of Molecular Sciences
|December 11, 2019
PubMed
Summary

Synaptic plasticity, the brain

Keywords:
Alzheimer’s disease (AD)brain networksconnectivitylong-term potentiation (LTP)resting state functional MRI (rs-fMRI)schizophreniasynaptic plasticitysynaptic scaling

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3D Modeling of Dendritic Spines with Synaptic Plasticity
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Area of Science:

  • Neuroscience
  • Systems Neuroscience
  • Computational Neuroscience

Background:

  • Brain network connectivity studies enhance understanding of brain adaptation to pathologies.
  • Synaptic plasticity, the modification of neuronal connections, is crucial for brain network remodeling after damage.

Purpose of the Study:

  • To review how synaptic plasticity mechanisms shape brain network organization.
  • To explore the role of different plasticity forms in network characteristics and reorganization after damage.

Main Methods:

  • Literature review of synaptic plasticity mechanisms and their relation to brain network organization.
  • Discussion of homeostatic and anti-homeostatic plasticity roles in network architecture.

Main Results:

  • Long-term potentiation may underlie the formation of highly connected brain network hubs.
  • Homeostatic plasticity might stabilize network activity by regulating peripheral node connectivity.
  • Dysfunctional synaptic plasticity is linked to brain network disruption in neuropsychiatric disorders.

Conclusions:

  • Synaptic plasticity is a key determinant of brain network architecture and resilience.
  • The balance between different plasticity forms is essential for efficient information processing and post-damage reorganization.