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Updated: Jan 2, 2026

Whole-cell Currents Induced by Puff Application of GABA in Brain Slices
Published on: October 12, 2017
Mu opioid receptors inhibit GABA release from parvalbumin interneuron terminals onto CA1 pyramidal cells
Caifeng Shao1, Pei Chen2, Qian Chen3
1Department of Anesthesiology, Nantong Hospital of Traditional Chinese Medicine, Nantong, Jiangsu, 226001, China; Department of Anatomy, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, 212013, China.
Abstract:
Selectively activating (by optogenetics) parvalbumin-expressing (PV) interneurons induces GABA release onto CA1 pyramidal cells. Here we report that this release was attenuated by presynaptic mu opioid receptors (MORs) activation. On the other hand, conventional electric shock, presumably activating non-selectively presynaptic GABAergic terminals, also induced GABA release; however, this release showed relatively limited depression by MORs activation. The data suggest that MORs specifically inhibit GABA release from PV terminals and therefore, further support the idea that MORs contribute to homeostasis in CA1 neuro-circuit.
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