Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heterochromatin02:38

Heterochromatin

17.7K
The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions that take up more dye are called heterochromatin. Heterochromatin is further classified into two forms – constitutive heterochromatin and facultative heterochromatin.
Constitutive heterochromatin: It is a highly compact region of chromatin that is mostly concentrated in the centromere and telomere. Unlike euchromatin, the amino acid at...
17.7K
Heterochromatin02:38

Heterochromatin

4.5K
4.5K
Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

587
Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
587
Viral Structure00:56

Viral Structure

73.6K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
73.6K
Duplication of Chromatin Structure02:05

Duplication of Chromatin Structure

7.1K
The process of chromosome duplication during cell division requires genome-wide disruption and re-assembly of chromatin. The chromatin structure must be accurately inherited, reassembled, and maintained in the daughter cells to ensure lineage propagation.
The basic unit of the chromatin is the nucleosome, consisting of DNA wrapped around octameric histone proteins and short stretches of linker DNA separating individual nucleosomes. The histone proteins within the nucleosome have their...
7.1K
DNA Bacteriophages01:26

DNA Bacteriophages

688
Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...
688

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A framework for the exploration of subcellular compartmentalization of RNA-binding proteins.

Nature communications·2026
Same author

Deciphering tissue-specific protein regulation for insights into cardiometabolic disease.

Molecular metabolism·2025
Same author

Chromatin activity of IκBα mediates the exit from naïve pluripotency.

eLife·2025
Same author

KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma.

Cancer research·2025
Same author

The PRC2-associated factor EPOP is required for Hox gene regulation during axial development in mice.

Developmental biology·2025
Same author

Herpes simplex virus type 1 reshapes host chromatin architecture via transcription machinery hijacking.

Nature communications·2025

Related Experiment Video

Updated: Jan 2, 2026

The MultiBac Protein Complex Production Platform at the EMBL
13:51

The MultiBac Protein Complex Production Platform at the EMBL

Published on: July 11, 2013

16.5K

The Bivalent Genome: Characterization, Structure, and Regulation.

Enrique Blanco1, Mar González-Ramírez1, Anna Alcaine-Colet1

  • 1Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Carrer del Doctor Aiguader 88, 08003 Barcelona, Spain.

Trends in Genetics : TIG
|December 11, 2019
PubMed
Summary
This summary is machine-generated.

Bivalent promoters and poised enhancers, marked by dual histone signals, control gene expression during development. Understanding these marks offers insights into cellular differentiation and potential links to cancer.

Keywords:
bivalencycancercell differentiationepigeneticshistone marksstem cells

More Related Videos

Author Spotlight: Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates
09:13

Author Spotlight: Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates

Published on: May 12, 2023

4.2K
Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses
12:20

Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses

Published on: December 29, 2015

21.9K

Related Experiment Videos

Last Updated: Jan 2, 2026

The MultiBac Protein Complex Production Platform at the EMBL
13:51

The MultiBac Protein Complex Production Platform at the EMBL

Published on: July 11, 2013

16.5K
Author Spotlight: Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates
09:13

Author Spotlight: Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates

Published on: May 12, 2023

4.2K
Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses
12:20

Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses

Published on: December 29, 2015

21.9K

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Epigenetics

Background:

  • Gene expression regulation is vital for cellular function and organismal development.
  • Bivalent promoters and poised enhancers are key regulatory elements in the genome.
  • These regions possess dual histone marks, indicating potential for both activation and repression.

Purpose of the Study:

  • To explore the origins and maintenance mechanisms of bivalent promoters.
  • To review the influence of bivalent marks on genome architecture.
  • To highlight the potential connection between bivalency and cancer.

Main Methods:

  • Literature review and synthesis of existing research on bivalent promoters and enhancers.
  • Analysis of epigenetic marks and their role in transcriptional regulation.
  • Exploration of genome organization in relation to bivalent states.

Main Results:

  • Bivalent marks establish a poised state for genes, crucial for developmental transitions.
  • Mechanisms for the acquisition and maintenance of bivalent promoters are discussed.
  • Bivalency impacts genome architecture and may be linked to cellular plasticity.

Conclusions:

  • Bivalent regulatory elements are critical for precise gene expression control during development.
  • Further research into bivalency could illuminate disease mechanisms, particularly cancer.
  • Understanding bivalent marks may offer new avenues for therapeutic interventions.