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Liver injury due to verapamil
J M Burgunder1, D R Abernethy, B H Lauterburg
1Department of Clinical Pharmacology, University of Berne, CH-Switzerland.
Hepato-Gastroenterology
|August 1, 1988
Abstract:
A 56-year-old female patient on verapamil for hypertension experienced two episodes of jaundice, pruritus and upper abdominal pain with transaminase elevated up to six-fold and alkaline phosphatase up to four-fold when inadvertently re-challenged with the drug. Liver biopsy showed marked cholestasis. Verapamil can occasionally cause mixed cytotoxic-cholestatic liver injury.