Nitrogen-doped carbon quantum dots embedded Co₃O₄ with multiwall carbon nanotubes: An efficient probe for the...

Area of Science:

• Electrochemistry
• Nanomaterials
• Analytical Chemistry
• Pharmaceutical Analysis

Background:

• Simultaneous determination of drugs in biological samples is vital for effective therapeutic drug monitoring.
• Existing methods may lack the required speed and sensitivity for real-time drug analysis.
• Need for advanced sensors to accurately quantify multiple pharmaceutical compounds concurrently.

Purpose of the Study:

• To develop a novel electrochemical sensor for the simultaneous quantification of Flutamide (FLU) and Nitrofurantoin (NF).
• To investigate the electrochemical behavior and performance of the developed sensor.
• To assess the sensor's applicability in real biological sample analysis for drug monitoring.

Main Methods:

• Fabrication of a glassy carbon electrode (GCE) modified with N-CQD@Co3O4/MWCNTs hybrid nanocomposite.
• Electrochemical characterization using cyclic voltammetry (CV) to study electro-kinetics.
• Performance evaluation using CV and differential pulse voltammetry (DPV) for simultaneous detection of FLU and NF.

Main Results:

• The N-CQD@Co3O4/MWCNTs/GCE sensor demonstrated efficient electro-kinetics.
• Achieved excellent sensitivity and selectivity for simultaneous determination of FLU and NF.
• Reported linear ranges of 0.05-590 μM for FLU and 0.05-1220 μM for NF, with low detection limits (0.0169 μM for FLU, 0.044 μM for NF).

Conclusions:

• The developed electrochemical sensor provides a fast, sensitive, and reliable platform for simultaneous drug analysis.
• The N-CQD@Co3O4/MWCNTs/GCE sensor shows significant potential for therapeutic drug monitoring in clinical settings.
• Satisfactory performance in real sample analysis validates the sensor's practical utility.