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Pharmacogenomics And Hypertension: Current Insights
Gustavo H Oliveira-Paula1,2, Sherliane C Pereira2, Jose E Tanus-Santos2
1Department of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, New York, NY, USA.
Pharmacogenomics and Personalized Medicine
|December 11, 2019
Summary
Genetic variations influence how patients respond to hypertension medications. Understanding these genetic factors is key to improving blood pressure control and preventing cardiovascular events.
Area of Science:
- Pharmacogenomics
- Cardiovascular Medicine
- Genetics
Background:
- Hypertension affects one billion people globally, increasing cardiovascular event risk.
- Effective blood pressure control is suboptimal in about two-thirds of patients.
- Interpatient variability in antihypertensive drug response is linked to genetic polymorphisms.
Purpose of the Study:
- To review recent findings on the pharmacogenomics of major antihypertensive drug classes.
- To discuss gene-gene interactions in hypertension pharmacogenomics.
- To highlight limitations and clinical implementation challenges.
Main Methods:
- Comprehensive literature review of pharmacogenomics studies.
- Analysis of genetic polymorphisms' effects on drug response.
- Inclusion of candidate gene, genome-wide, and gene-gene interaction approaches.
Main Results:
- Genetic polymorphisms significantly impact responses to diuretics, beta-blockers, ACE inhibitors, ARBs, and CCBs.
- Gene-gene interactions offer a more nuanced understanding of hypertension pharmacogenomics.
- Inconsistencies and limitations exist within current research.
Conclusions:
- Pharmacogenomics holds promise for personalized hypertension treatment.
- Further research is needed to address inconsistencies and challenges.
- Clinical implementation of pharmacogenomics requires overcoming practical hurdles.
Keywords:
GWASantihypertensive therapycandidate genesgene-gene interactionshypertensionpharmacogenomicsMore Related Videos
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