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Dynamic thiol/disulphide homeostasis in patients with hypertrophic cardiomyopathy

Munevver Sari1, Unal Erkorkmaz2, Hayrullah Yazar3

  • 1Department of Cardiology, University of Health Sciences, Kartal Kosuyolu Education and Research Hospital, Denizer street, 34865, Kartal/Istanbul, Turkey. benmsr@hotmail.com.

Herz
|December 11, 2019
PubMed

Insights

Patients with hypertrophic cardiomyopathy (HCM) exhibit altered serum thiol/disulphide homeostasis, indicating impaired antioxidant capacity. This suggests a potential link between HCM and oxidative stress similar to that observed in tumors.

Area of Science:

  • Biochemistry
  • Cardiology
  • Oxidative Stress Research

Background:

  • Hypertrophic cardiomyopathy (HCM) presents complex genetic factors and variable clinical outcomes.
  • Investigating non-genetic factors like oxidative stress is crucial for understanding HCM's heterogeneity.

Purpose of the Study:

  • To evaluate serum thiol/disulphide homeostasis as a marker of oxidative stress in patients with HCM.
  • To utilize a novel automated assay for precise measurement of thiol/disulphide balance.

Main Methods:

  • A cross-sectional study involving 119 HCM patients and 52 controls.
  • Measurement of dynamic thiol/disulphide homeostasis using calorimetric and duplex methods developed in 2014.

Main Results:

  • HCM patients showed significantly lower serum native thiol, total thiol, and disulphide levels compared to controls.
  • Disulphide/native thiol and disulphide/total thiol ratios were significantly lower in HCM patients.
  • Reduced thiol ratios were higher, and oxidized thiol ratios were lower in HCM patients, indicating impaired antioxidant capacity.

Conclusions:

  • HCM patients exhibit impaired antioxidant capacity, with serum thiol/disulphide homeostasis shifted towards a reducing state.
  • The study speculates that HCM may share similarities with tumors regarding serum thiol-disulphide level alterations.
Abstract

Keywords:
AntioxidantHypertrophic cardiomyopathyOxidative stressThiol/disulphide homeostasis

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