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Renal involvement in paediatric inflammatory bowel disease
1Department of Paediatric Gastroenterology, Evelina London Children' Hospital, Westminster Bridge Road, London, SE1 7EH, UK. Mohamed.mutalib@gstt.nhs.uk.
Pediatric Nephrology (Berlin, Germany)
|December 11, 2019
Summary
Inflammatory bowel disease (IBD) can affect the kidneys, often as an extraintestinal manifestation or due to medications. Renal issues in IBD patients range from mild abnormalities to severe impairment, impacting morbidity and mortality.
Area of Science:
- Gastroenterology
- Nephrology
- Pediatrics
Background:
- Inflammatory bowel disease (IBD) is a chronic GI disorder with rising incidence in children and adults.
- IBD symptoms arise from an interplay between environment, microbiome, and host immunity in susceptible individuals.
- Extraintestinal manifestations (EIMs) are common in IBD, affecting various organ systems.
Purpose of the Study:
- To review the renal manifestations of IBD.
- To highlight the spectrum of kidney involvement in IBD patients, particularly in children.
- To discuss the impact of IBD and its treatments on renal health.
Main Methods:
- Literature review of renal involvement in IBD.
- Analysis of IBD-associated renal complications.
- Examination of treatment-related nephrotoxicity in IBD.
Main Results:
- Renal involvement in IBD is uncommon but significant.
- Kidney issues can manifest as EIMs or metabolic complications.
- IBD medications can lead to renal damage.
- Renal manifestations in pediatric IBD range from biochemical abnormalities to severe impairment.
Conclusions:
- Renal complications are an important consideration in the management of IBD.
- Early recognition and management of renal issues are crucial for improving outcomes in IBD patients.
- Further research is needed to elucidate the mechanisms and optimize the treatment of renal manifestations in IBD.
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