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Trace Element Status and Hypothyroidism: A Systematic Review and Meta-analysis
Sepide Talebi1, Ehsan Ghaedi2,3, Erfan Sadeghi4,5
1Student Research Committee, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Biological Trace Element Research
|December 11, 2019
Summary
Hypothyroidism is linked to lower selenium and zinc levels and higher lead levels in patients compared to healthy individuals. Further research is needed to clarify these trace element associations.
Area of Science:
- Endocrinology
- Nutritional Science
- Toxicology
Background:
- Thyroid hormone metabolism is plausibly linked to trace element levels.
- Previous studies on trace elements in hypothyroidism show conflicting results.
- Understanding these associations is crucial for managing thyroid disorders.
Purpose of the Study:
- To conduct a meta-analysis investigating trace element concentrations in hypothyroidism.
- To compare selenium, zinc, iron, manganese, copper, lead, and magnesium levels in hypothyroid patients versus healthy controls.
Main Methods:
- Systematic literature search of PubMed, Scopus, Embase, and Science Direct databases.
- Inclusion of 32 observational studies in the final meta-analysis.
- Utilized Hedges' g test to calculate effect sizes for trace element concentrations.
Main Results:
- Significantly lower selenium and zinc concentrations in hypothyroid patients.
- Significantly higher lead concentrations in hypothyroid patients.
- No significant differences in iron, copper, manganese, or magnesium levels were observed.
Conclusions:
- Hypothyroidism is associated with altered levels of specific trace elements, notably lower selenium and zinc, and higher lead.
- These findings highlight potential diagnostic or therapeutic targets.
- Further high-quality, large-scale studies are recommended to confirm and elucidate these trace element-hypothyroidism links.
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