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Updated: Jan 2, 2026

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
How do I … implement diagnostic management teams in transfusion medicine?
Jenna Wade1, Christina L Dean1, Scott M Krummey1
1Center for Transfusion and Cellular Therapy, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia.
Diagnostic management teams (DMTs) improve patient care by integrating diagnostic experts and clinicians. This approach enhances accurate diagnosis and reduces healthcare costs through optimized testing for conditions like platelet refractoriness.
Area of Science:
- Clinical Medicine
- Laboratory Diagnostics
- Healthcare Management
Background:
- Increasing medical subspecialization necessitates collaborative diagnostic approaches.
- Diagnostic management teams (DMTs) bridge the gap between diagnostic experts and clinicians.
- DMTs aim to enhance diagnostic accuracy, timeliness, and cost-effectiveness.
Purpose of the Study:
- To describe the development and implementation of a formal platelet refractory (PR) laboratory consult within a transfusion medicine (TM) service.
- To improve the diagnostic management and reduce delays in treatment for PR patients.
- To align with National Academy of Medicine recommendations for diagnostic stewardship.
Main Methods:
- Established a formal PR laboratory consult as a Diagnostic Management Team (DMT) initiative.
- Integrated diagnostic expertise for complex laboratory test interpretation and utilization.
- Uploaded comprehensive test result interpretations to the patient's electronic medical record (EMR).
Main Results:
- Streamlined workup and management protocols for PR patients.
- Facilitated appropriate and timely provision of compatible platelet units.
- Enabled compensation for PR evaluations via CPT codes linked to EMR entries.
Conclusions:
- The implemented DMT model successfully improved diagnostic management for PR patients.
- This collaborative approach enhances patient care, safety, and healthcare efficiency.
- The PR laboratory consult serves as a successful example of DMT principles in practice.
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