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Enabling Free-Standing 3D Hydrogel Microstructures with Microreactive Inkjet Printing.

Mei Ying Teo, Seyoung Kee, Narrendar RaviChandran

    ACS Applied Materials & Interfaces
    |December 11, 2019
    PubMed
    Summary

    Microreactive inkjet printing (MRIJP) enables spontaneous 3D printing of hydrogel microstructures. This technique precisely controls hydrogel shape and fabrication for advanced 2D/3D microstructure printing.

    Keywords:
    3D printingalginate hydrogelsdroplet collisionsevaporation ratereactive inkjet printing

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    Area of Science:

    • Materials Science
    • Biotechnology
    • Additive Manufacturing

    Background:

    • Reactive inkjet printing offers precise control for fabricating complex hydrogel structures.
    • Current methods are limited by challenges in controlling gelation and motion during printing.

    Purpose of the Study:

    • To demonstrate spontaneous 3D printing of hydrogel microstructures using microreactive inkjet printing (MRIJP).
    • To identify key parameters influencing hydrogel shape and fabrication in MRIJP.

    Main Methods:

    • Utilized alginate as a model system for MRIJP of hydrogel microstructures.
    • Investigated the relationship between fluid dynamics (capillary number, Weber number) and droplet collision.
    • Analyzed the impact of hydrogel structure and diffusion coefficients on printed shapes over time.

    Main Results:

    • Successfully demonstrated spontaneous 3D printing of hydrogel microstructures via MRIJP.
    • Identified a printable window for in-air binary droplet collision, highlighting the role of velocity.
    • Established that hydrogel properties significantly affect the morphology of printed structures.

    Conclusions:

    • MRIJP provides a robust method for fabricating intricate 2D/3D hydrogel microstructures.
    • Fundamental understanding of MRIJP allows for controlled fabrication of tissue-mimicking structures with precise dimensions.