Related Experiment Video
Updated: Jan 2, 2026

Lethality Bioassay Using Artemia salina L.
Published on: October 11, 2022
Cytotoxic p-Terphenyls from a Marine-Derived Nocardiopsis Species
Dongyang Wang1, Yi Wang1, Yinfeng Ouyang1
1Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy , Ocean University of China , Qingdao 266003 , China.
Abstract:
Three new p-terphenyl derivatives, nocarterphenyls A-C (1-3), along with three known analogues (4-6) were isolated from the marine-derived actinobacterial strain Nocardiopsis sp. OUCMDZ-4936. Their structures were elucidated on the basis of spectroscopic analysis and a single-crystal X-ray diffraction experiment. Compounds 1 and 2 possess a benzothiazole and benzothiazine moiety, respectively, which are rare in the skeleton of p-terphenyls. Nocarterphenyl A (1) showed potent cytotoxic activity against the HL60 and HCC1954 cancer cell lines with the IC50 values of 0.38 and 0.10 μM among 26 human cancer cell lines.
Related Concept Videos
Diversity of Protists II
Physical Properties of Amines

