Related Experiment Videos
Rifampicin-isoniazid and delayed elimination of theophylline: a case report
R Dal Negro1, P Turco, F Trevisan
1Lung Pathophysiology Laboratory, Bussolengo Hospital, Verona, Italy.
International Journal of Clinical Pharmacology Research
|January 1, 1988
Abstract:
This paper reports a case of tuberculosis relapse and chronic obstructive lung disease treated with rifampicin and isoniazid. The subsequent introduction of slow-release theophylline therapy revealed a delay in the theophylline elimination kinetics resulting in a toxic plasma level. Interference with hepatic microsomal enzymes is considered to occur.