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Septic arthritis in sickle cell disease
M Sankaran-Kutty1, M Sadat-Ali, M K Kutty
1Department of Orthopaedics, King Fahd University Hospital, King Faisal University, Al-Khobar, Saudi Arabia.
International Orthopaedics
|January 1, 1988
Summary
Septic arthritis in sickle cell disease patients is serious. Staphylococcus aureus is the most common cause, and prompt surgical drainage with chemotherapy offers the best treatment outcomes.
Area of Science:
- Orthopedics
- Infectious Diseases
- Hematology
Background:
- Sickle cell disease (SCD) is a genetic blood disorder associated with various complications.
- Septic arthritis, a severe joint infection, can occur as an orthopedic complication in SCD patients.
- Understanding the causative organisms and optimal management is crucial for SCD patients.
Purpose of the Study:
- To prospectively investigate the characteristics of septic arthritis in patients with sickle cell disease.
- To identify the common causative pathogens.
- To describe the clinical presentation, sequelae, and evaluate treatment efficacy.
Main Methods:
- Prospective study enrolling fourteen patients with sickle cell disease and septic arthritis.
- Analysis of patient demographics, clinical features, causative organisms, and treatment regimens.
- Assessment of treatment outcomes and long-term sequelae.
Main Results:
- Septic arthritis represented 11% of orthopedic complications in 129 SCD patients studied.
- Staphylococcus aureus was the predominant pathogen, identified in eleven of the fourteen cases.
- Salmonella species were identified in two cases.
Conclusions:
- Septic arthritis is a significant orthopedic complication in sickle cell disease.
- Staphylococcus aureus is the most frequent causative agent.
- Open surgical drainage combined with intensive chemotherapy is the recommended treatment approach.