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Related Experiment Video

Updated: Jan 2, 2026

Training Persons with Spinal Cord Injury to Ambulate Using a Powered Exoskeleton
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Exoskeleton-assisted Gait Training in Persons With Multiple Sclerosis: A Single-Group Pilot Study.

Taimoor Afzal1, Shih-Chiao Tseng2, John A Lincoln3

  • 1Department of Physical Medicine and Rehabilitation, the University of Texas Health Science Center at Houston, Houston, Texas; Center for Wearable Exoskeletons, NeuroRecovery Research Center, TIRR Memorial Hermann, Houston, Texas.

Archives of Physical Medicine and Rehabilitation
|December 11, 2019
PubMed
Summary

Exoskeleton-assisted gait training (EGT) is feasible for individuals with multiple sclerosis (MS). This training improved gait speed and reduced metabolic expenditure, suggesting potential benefits for MS rehabilitation.

Keywords:
Exoskeleton deviceGaitMetabolismMultiple sclerosisRehabilitation

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Biomedical Engineering

Background:

  • Multiple Sclerosis (MS) significantly impacts gait and physical function.
  • Current rehabilitation strategies for MS may have limitations in addressing gait impairments.

Purpose of the Study:

  • To assess the feasibility of exoskeleton-assisted gait training (EGT) in individuals with MS.
  • To evaluate the effects of EGT on gait parameters, metabolic cost, and physical function in MS patients.

Main Methods:

  • A single-group pilot study was conducted in a rehabilitation hospital setting.
  • Ten participants with MS (Expanded Disability Status Scale 6.0-7.5) underwent up to 15 EGT sessions.
  • Gait speed, 6-minute walk test, metabolic expenditure, and Timed Up and Go test were measured pre- and post-training.

Main Results:

  • All participants tolerated EGT without adverse events.
  • Significant improvements in gait speed were observed during the timed 25-foot walk test at self-selected speed.
  • Reduced metabolic expenditure during walking was noted post-training.

Conclusions:

  • Exoskeleton-assisted gait training is a feasible intervention for individuals with MS.
  • EGT may enhance gait efficiency and reduce metabolic cost, potentially due to improved neuromotor coordination.
  • Further research is warranted to establish the efficacy of EGT in MS rehabilitation.