Relapses after using Carnoy's solution in treating aggressive benign odontogenic lesions

Chemical curettage has become popular in the definitive treatment of benign aggressive odontogenic lesions. Therefore, this study aims to verify the relapse rate and associated factors after the enucleation protocol, peripheral ostectomy and Carnoy's solution.

This is a retrospective sectional study with 30 patients, selected by non-probabilistic convenience sampling, submitted to the protocol from 2008 to 2018. The study was composed by the data collection phase of the medical records and clinical and radiographic analysis of the patients in order to verify the presence of relapses. Descriptive and statistical analyzes were performed using the Stata/IC version 14.0 program (StataCorp, College Station, TX, USA). The Mann-Whitney Test, Fisher's Exact Test and the χ2 Test, as well as the Kaplan Meier method and the Log-rank Test were used to verify the possible prognostic factors for relapses, adopting P<0.05.

The sample consisted of 22 patients with odontogenic keratocysts (73.3%), 3 odontogenic myxomas (10%) and 5 ameloblastomas (16.7%). Relapses affected 7 patients (23.3%), all in odontogenic keratocysts, and the relapse time was between 12-34 months. There was no statistical difference between the evaluated factors and relapse development. Patients who remained with teeth adjacent to the lesion after treatment had an earlier relapse time, a cumulative risk of more than 80% for relapse after 29 months postoperatively, and a 5.5 times greater chance of developing relapses than patients who had their teeth extracted.

The protocol is advantageous when compared to isolated treatments and can be used as an alternative to resection.