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Related Experiment Videos

Cefoxitin therapy for surgical patients.

W M Rambo1, V E Del Bene, D K Delamar

  • 1Department of Medicine, Medical University of South Carolina, Charleston.

Reviews of Infectious Diseases
|January 1, 1979
PubMed
Summary

Cefoxitin effectively treated surgical infections in 25 patients, showing good tolerance and eliminating common bacteria. This antibiotic shows promise as a replacement for combination therapy in certain surgical cases.

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Area of Science:

  • Infectious Diseases
  • Surgical Infections
  • Pharmacology

Background:

  • Surgical site infections pose significant clinical challenges.
  • Effective antibiotic therapy is crucial for managing these infections.
  • Cefoxitin is a cephalosporin antibiotic with broad-spectrum activity.

Purpose of the Study:

  • To evaluate the efficacy and tolerability of cefoxitin in patients on a general surgical service.
  • To assess the susceptibility of common surgical pathogens to cefoxitin.
  • To determine if cefoxitin can replace combination antibiotic therapy.

Main Methods:

  • Cefoxitin was administered to 25 surgical patients with bacteriologically diagnosed infections.
  • Dosages ranged from 4 to 8 g per day.
  • Bacteriologic cultures and patient outcomes were monitored.

Main Results:

  • 16 patients had infections including peritonitis, cholangitis, cellulitis, and abscess.
  • Cefoxitin was well tolerated, with minor side effects (phlebitis, superinfection).
  • No renal, liver, or bone marrow toxicity was observed. All tested Bacteroides, E. coli, and S. aureus isolates were sensitive; Pseudomonas aeruginosa showed resistance in 2/3 strains.
  • All patients recovered with cefoxitin and surgery.

Conclusions:

  • Cefoxitin demonstrated efficacy in treating a range of surgical infections.
  • The antibiotic was generally well-tolerated with no significant organ toxicity.
  • Cefoxitin may offer an alternative to combination therapy for specific surgical infections.

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