Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.2K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.2K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

908
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
908
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.1K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immediate splenectomy down-regulates the MAPK-NF-κB signaling pathway in rat brain after severe traumatic brain injury.

The journal of trauma and acute care surgery·2013
Same author

Novel TRPM6 mutations in familial hypomagnesemia with secondary hypocalcemia.

American journal of nephrology·2013
Same author

A novel technique of modified continuous blanket suture for amniotic membrane fixation in severe ocular surface diseases.

JAMA ophthalmology·2013
Same author

[Clinical manifestations, therapeutic response to tyrosinase inhibitor and RET gene activating mutation in a patient with multiple endocrine neoplasia 2B].

Zhonghua yi xue za zhi·2013
Same author

A hypomorphic lsd1 allele results in heart development defects in mice.

PloS one·2013
Same author

Spectroscopic study of the light-harvesting CP29 antenna complex of photosystem II--part I.

The journal of physical chemistry. B·2013

Related Experiment Video

Updated: Jan 2, 2026

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
09:03

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Published on: June 20, 2015

10.4K

Structure-function relationship between Bruch's membrane opening-minimum rim width and perimetry in open-angle

Ruoshi Li1, Xia Wang1, Yahui Wei1

  • 1Department of Ophthalmology, Peking University First Hospital, No.8 Xi Shi Ku Street, Xi Cheng District, 100034, Beijing, People's Republic of China.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|December 12, 2019
PubMed
Summary

Bruch

Keywords:
Bruch’s membrane opening-minimum rim widthNormal-tension glaucomaOptical coherence tomographyPrimary open-angle glaucomaStructure–function relationship

More Related Videos

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.7K
Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
08:55

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Published on: April 24, 2020

3.4K

Related Experiment Videos

Last Updated: Jan 2, 2026

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
09:03

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Published on: June 20, 2015

10.4K
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.7K
Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
08:55

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Published on: April 24, 2020

3.4K

Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Neuroscience

Background:

  • Glaucoma is a leading cause of irreversible blindness.
  • Early detection of glaucoma is crucial for preventing vision loss.
  • Bruch's membrane opening-minimum rim width (BMO-MRW) is a key structural parameter in glaucoma assessment.

Purpose of the Study:

  • Determine the threshold of BMO-MRW associated with visual field (VF) damage in open-angle glaucoma (OAG).
  • Investigate structural differences in BMO-MRW between primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG).

Main Methods:

  • Recruited 83 healthy and 106 glaucoma subjects (49 POAG, 57 NTG).
  • Performed optical coherence tomography (OCT) and Humphrey visual field (VF) testing.
  • Correlated BMO-MRW with VF using a broken-stick statistical model to identify structural-functional relationships and tipping points.

Main Results:

  • The global BMO-MRW tipping point for VF impairment was 234.38 μm (OAG), 228.09 μm (POAG), and 249.68 μm (NTG).
  • The slope of BMO-MRW loss was steeper below the tipping point in all quadrants (p < 0.001).
  • NTG showed smaller tipping points than POAG, particularly in the inferotemporal quadrant.

Conclusions:

  • Bruch's membrane opening-minimum rim width loss may precede detectable visual field impairment in OAG.
  • Normal-tension glaucoma patients exhibit more severe BMO-MRW damage than POAG patients at the onset of VF defects.