DCO₂/PaCO₂ correlation on high-frequency oscillatory ventilation combined with volume guarantee using increasing...

To examine the correlation DCO₂/PaCO₂ on high-frequency oscillatory ventilation (HFOV) combined with volume guarantee (VG) throughout increasing frequencies in two different respiratory conditions, physiological and low compliance. Neonatal animal model was used, before and after a bronchoalveolar lavage (BAL). HFOV combined with VG was used. The frequency was increased from 10 to 20 Hz, and high-frequency tidal volume (VThf) was gradually decreased maintaining a constant DCO₂. Arterial partial pressure of carbon dioxide (PaCO₂) was evaluated after each frequency and VThf change. Six 2-day-old piglets were studied. A linear decrease in PaCO₂ was observed throughout increasing frequencies in both respiratory conditions while maintaining a constant DCO₂, showing a significant difference between the initial PaCO₂ (at 10 Hz) and the PaCO₂ obtained at 18 and 20 Hz. A new DCO₂ equation (corrected DCO₂) was calculated in order to better define the correlation between DCO₂ and the observed PaCO₂.Conclusion: The correlation DCO₂/PaCO₂ throughout increasing frequencies is not linear, showing a greater CO₂ elimination efficiency at higher frequencies, in spite of maintaining a constant DCO₂. So, using frequencies close to the resonant frequency of the respiratory system on HFOV combined with VG, optimizes the efficiency of gas exchange.What is Known: • The efficacy of CO₂removal during high-frequency oscillatory ventilation (HFOV), described as the diffusion coefficient of CO₂(DCO₂) is related to the square of the high-frequency tidal volume (VThf) and the frequency (f), expressed as DCO₂= VThf²× f.What is New: • The correlation between DCO₂and PaCO₂throughout increasing frequencies is not linear, showing a greater CO₂elimination efficiency at higher frequencies. So, using very high frequencies on HFOV combined with volume guarantee optimizes the efficiency of gas exchange allowing to minimize lung injury.