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Aging with HIV.

Giovanni Guaraldi1, Jovana Milic2,3, Cristina Mussini2

  • 1Department of Surgical, Medical, Dental and Morphological Sciences with Interest transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy. giovanni.guaraldi@unimore.it.

Current HIV/AIDS Reports
|December 12, 2019
PubMed
Summary
This summary is machine-generated.

Older adults with HIV experience unique aging challenges, including chronic inflammation and comorbidities. A geriatric approach is crucial for managing complex health needs beyond viral suppression.

Keywords:
AgingAntiretroviral therapyFrailtyGeriatric medicineHIV

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Area of Science:

  • Geriatric Medicine
  • Infectious Diseases
  • HIV Research

Background:

  • Aging with HIV presents a complex interplay of chronic inflammation and immune activation.
  • HIV accelerates aging trajectories, influenced by antiretroviral therapy and comorbidities.

Purpose of the Study:

  • To review unmet medical needs and research questions in older adults living with HIV.
  • To explore the multifaceted aspects of aging with HIV, including epidemiological, pathophysiological, and clinical dimensions.
  • To critically discuss antiretroviral management and care models for this population.

Main Methods:

  • Literature review focusing on aging in HIV.
  • Analysis of epidemiological, pathophysiological, and clinical data.
  • Critical discussion of current treatment and care strategies.

Main Results:

  • HIV serves as a model for accelerated aging due to chronic inflammation and immune activation.
  • Antiretroviral therapy's role in aging with HIV is complex, influenced by infection duration and comorbidities.
  • Current management often overlooks geriatric complexities, necessitating a shift in approach.

Conclusions:

  • A geriatric approach is essential for addressing the comprehensive needs of aging individuals with HIV.
  • Recognizing frailty and geriatric syndromes is key to stratifying patient diversity.
  • Comprehensive geriatric assessment tools are vital for effective management beyond viro-immunological success.