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Transdermal Methanol Intoxication.

Ahmet Burak Oguz1, Muge Gunalp1, Onur Polat1

  • 1Ankara University School of Medicine Department of Emergency Medicine, Ankara, Turkey.

Archives of Iranian Medicine
|December 12, 2019
PubMed
Summary
This summary is machine-generated.

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Transdermal methanol intoxication is rare but possible. A case study highlights methanol absorption through skin via a soaked bandage, leading to severe metabolic acidosis and neurological symptoms.

Area of Science:

  • Toxicology
  • Dermatology
  • Emergency Medicine

Background:

  • Methanol is a toxic alcohol commonly ingested orally.
  • Transdermal absorption of methanol is an uncommon route of intoxication.
  • Methanol poisoning can cause severe metabolic acidosis and neurological deficits.

Observation:

  • A 58-year-old woman presented with diplopia, nausea, vomiting, and dizziness.
  • Physical examination revealed a hyperemic lesion on her knee.
  • The patient had applied a methanol-soaked bandage to her knee for pain relief.

Findings:

  • The patient exhibited high osmolar gap and high anion-gap metabolic acidosis (HAGMA).
  • Serum methanol levels were significantly elevated at 37.9 mg/dL.
  • Diagnosis of transdermal methanol intoxication was confirmed.
Keywords:
DiplopiaIntoxicationMethanol

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Implications:

  • This case underscores the potential for methanol poisoning via transdermal absorption.
  • Clinicians should consider methanol toxicity in patients with unexplained metabolic acidosis and neurological symptoms, regardless of the route of exposure.
  • Prompt treatment including bicarbonate, ethyl alcohol, and hemodialysis can prevent long-term sequelae.