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Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Overview
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The Functions of the Skeletal System01:22

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The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
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Satellite Stem Cells and Muscular Dystrophy01:21

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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
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Chemical Synapses01:26

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Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
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Updated: Jan 2, 2026

Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents
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Neuromuscular Diseases and Bone.

Giovanni Iolascon1, Marco Paoletta1, Sara Liguori1

  • 1Department of Medical and Surgical Specialties and Dentistry, University of Campania "Luigi Vanvitelli", Naples, Italy.

Frontiers in Endocrinology
|December 12, 2019
PubMed
Summary
This summary is machine-generated.

Neuromuscular diseases (NMDs) compromise bone health through factors like poor nutrition, immobility, and medications. Early interventions and interdisciplinary care are crucial for managing skeletal complications in NMD patients.

Keywords:
fracturesglucocorticoidsneuromuscular diseasesosteoporosisphysical activityrehabilitationvitamin D

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Area of Science:

  • Orthopedics
  • Neurology
  • Endocrinology

Background:

  • Neuromuscular diseases (NMDs) affect muscles, nerves, and junctions, leading to progressive muscle weakness and reduced quality of life.
  • Skeletal health is often compromised in NMDs due to altered bone-muscle interactions, increasing fracture risk.
  • Patients with NMDs frequently experience malnutrition, immobility, and vitamin D deficiency, all impacting bone health.

Purpose of the Study:

  • To review the factors contributing to bone alterations in NMDs.
  • To elucidate how these factors affect bone health pathways.
  • To discuss current interventions for managing bone involvement in NMDs.

Main Methods:

  • Literature review of factors influencing bone health in NMDs.
  • Analysis of biological pathways affected by NMDs and related conditions.
  • Evaluation of pharmacological and non-pharmacological management strategies.

Main Results:

  • Bone alterations in NMDs result from biomechanical and bio-humoral changes, nutritional issues, immobility, and vitamin D deficiency.
  • Certain disease-modifying drugs, like glucocorticoids, can cause secondary osteoporosis.
  • Interventions should address musculoskeletal issues to improve functional independence and social implications.

Conclusions:

  • Bone health is significantly impacted in NMDs through multiple interconnected factors.
  • An interdisciplinary and multimodal management strategy is recommended for optimal patient care.
  • Targeting musculoskeletal issues is vital for enhancing functional independence and quality of life in NMD patients.