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Related Experiment Video

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Evaluation of Synapse Density in Hippocampal Rodent Brain Slices
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Adiponectin Knockout Mice Display Cognitive and Synaptic Deficits.

Jenna Bloemer1,2, Priyanka D Pinky1,2, Warren D Smith1,2

  • 1Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, United States.

Frontiers in Endocrinology
|December 12, 2019
PubMed
Summary

Adiponectin deficiency impairs cognitive function and hippocampal synaptic plasticity in mice. Restoring adiponectin receptor signaling improved long-term potentiation, highlighting adiponectin

Keywords:
AdipoR1AdipoR2AdipoRonadiponectincognitionsynaptic plasticity

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Area of Science:

  • Neuroscience
  • Metabolic Research
  • Molecular Biology

Background:

  • Adiponectin, an adipokine, is explored for neuroprotective roles in brain disorders.
  • Adiponectin receptors (AdipoR1, AdipoR2) are present in the hippocampus, but their synaptic and cognitive roles are unclear.

Purpose of the Study:

  • To investigate the impact of adiponectin absence on cognitive and hippocampal synaptic function.
  • To elucidate the role of adiponectin in regulating synaptic plasticity and neurotransmission.

Main Methods:

  • Utilized 12-month-old adiponectin knockout (APN-KO) mice and age-matched controls.
  • Assessed cognitive function using novel object recognition (NOR) and Y-maze tests.
  • Evaluated hippocampal synaptic function, including long-term potentiation (LTP) and basal synaptic transmission.

Main Results:

  • APN-KO mice exhibited significant cognitive deficits and impaired hippocampal LTP.
  • Reduced basal synaptic transmission and increased presynaptic release probability were observed in APN-KO mice.
  • Treatment with an adiponectin receptor agonist (AdipoRon) rescued LTP deficits.

Conclusions:

  • Adiponectin is a critical regulator of hippocampal synaptic function and cognitive performance.
  • Adiponectin receptor signaling directly influences synaptic plasticity and neurotransmission.
  • Further research is warranted to explore the specific roles of AdipoR1 and AdipoR2 in synaptic processes.