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A Porcine Model for Urinary Tract Infection
Thomas Kastberg Nielsen1, Nicky Anúel Petersen1, Kristian Stærk2
1Research Unit of Urology, Department of Clinical Research, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
Frontiers in Microbiology
|December 12, 2019
Summary
Researchers developed a novel large-animal model for urinary tract infections (UTIs) using pigs. This model mimics human anatomy and physiology, offering a better understanding of UTI pathogenesis beyond small rodent studies.
Area of Science:
- Veterinary Medicine
- Infectious Diseases
- Animal Models
Background:
- Urinary tract infection (UTI) is a common bacterial disease with high recurrence rates.
- Current research relies heavily on murine models, which show limitations in mimicking human UTI.
- A need exists for large-animal models that better reflect human anatomy and physiology for UTI studies.
Purpose of the Study:
- To establish the first large-animal model of cystitis using pigs.
- To create a model that mimics human UTI pathogenesis without invasive procedures or animal distress.
Main Methods:
- A non-invasive protocol was used to establish persistent, non-ascending infection in pigs.
- Infection was monitored via cystoscopy, bladder biopsies, and urine/blood analysis.
- Post-mortem analysis included bladder histology, microscopy, and bacterial counts.
Main Results:
- A reproducible large-animal model for cystitis was successfully established in pigs.
- The model demonstrated persistent, non-ascending infection without causing significant pain or discomfort.
- Comprehensive analysis confirmed infection establishment and characteristics.
Conclusions:
- This pig model represents a significant advancement for studying urinary tract infection pathogenesis.
- It offers a valuable tool to bridge the gap between small-animal models and human UTI.
- The model facilitates future research into UTI mechanisms and potential treatments.
