Related Experiment Video
Updated: Jan 2, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
Published on: December 31, 2013
Understanding diverse TRPV1 signaling - an update
1Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, OR, 97239, USA.
Abstract:
The transient receptor potential vanilloid 1 (TRPV1) is densely expressed in spinal sensory neurons as well as in cranial sensory neurons, including their central terminal endings. Recent work in the less familiar cranial sensory neurons, despite their many similarities with spinal sensory neurons, suggest that TRPV1 acts as a calcium channel to release a discrete population of synaptic vesicles. The modular and independent regulation of release offers new questions about nanodomain organization of release and selective actions of G protein-coupled receptors.
Related Concept Videos
Thermosensation
Diversity in Cell Signaling Responses
Graded and Abrupt Responses
Some signaling systems generate...
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Receptor Downregulation in MVBs
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
GPCR Desensitization
Signal Transduction: Overview
Typically, signal transduction involves three...

