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Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
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Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
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Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments
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An intrinsically disordered proteins community for ELIXIR.

Norman E Davey1, M Madan Babu2, Martin Blackledge3

  • 1Division of Cancer Biology, Institute of Cancer Research, UK, London, SW3 6JB, UK.

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|December 12, 2019
PubMed
Summary
This summary is machine-generated.

This white paper outlines a roadmap for developing essential e-infrastructure for intrinsically disordered protein (IDP) research. It focuses on creating tools and standards for IDP data analysis and functional characterization within the ELIXIR framework.

Keywords:
ELIXIRcellular regulationcommunity standardsdatabasesintrinsically disordered proteinsprotein dynamicsprotein functionprotein-protein interactions

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Area of Science:

  • Biochemistry and Molecular Biology
  • Bioinformatics
  • Computational Biology

Background:

  • Intrinsically disordered proteins (IDPs) and regions (IDRs) are crucial for cellular regulation.
  • Existing research infrastructure requires enhancement to fully support IDP studies.

Purpose of the Study:

  • To present a roadmap for e-infrastructure development in intrinsically disordered protein research.
  • To foster the creation of high-quality tools and resources for IDP identification, analysis, and functional characterization.
  • To establish a preliminary blueprint for an IDP Community within the ELIXIR framework.

Main Methods:

  • A workshop involving the IDP user community was conducted.
  • Community-wide consultation was performed to identify key priorities.
  • The roadmap integrates existing ELIXIR platforms and international consortia.

Main Results:

  • Key priority areas identified include data annotation, storage, and dissemination standards.
  • Integration of IDP data into ELIXIR Core Data Resources is a priority.
  • Development of benchmarking criteria for IDP-related software is recommended.

Conclusions:

  • The proposed roadmap aims to advance IDP research through improved e-infrastructure.
  • Cooperation with ELIXIR platforms and international consortia is essential for implementation.
  • The study calls for the involvement of new stakeholders to build a robust IDP Community.