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Asthma-II: Pathophysiology and Classification

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Critical processes in asthma pathophysiology include:

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Updated: Jan 2, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

Transcriptomic Analysis Links Eosinophilic Esophagitis and Atopic Dermatitis.

Rémi Doucet-Ladevèze¹, Sébastien Holvoet², Frédéric Raymond¹

¹Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.

Frontiers in Pediatrics

|December 12, 2019

Summary

Eosinophilic esophagitis (EoE) shares molecular pathways with atopic dermatitis (AD) and allergic airway (AA) diseases, particularly IL-13 driven ones. This suggests shared therapeutic strategies for these atopic conditions.

Keywords:

asthma atopic dermatitis eosinophilic esophagitis epithelial cells interleukin 13

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Last Updated: Jan 2, 2026

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Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

Area of Science:

Immunology
Genomics
Dermatology
Gastroenterology
Pulmonology

Background:

Eosinophilic esophagitis (EoE) frequently co-occurs with atopic dermatitis (AD) and allergic airway (AA) diseases.
Shared pathological features exist across these conditions, but unifying molecular pathways remain underexplored.

Purpose of the Study:

To compare mRNA expression profiles between EoE, AA, and AD.
To investigate the role of interleukin-13 (IL-13) in modulating gene expression across these diseases.

Main Methods:

Whole-genome mRNA expression analysis of tissue samples from EoE, AD, and AA patients.
Analysis of IL-13-stimulated primary human epithelial cells from esophagus, skin, and airways.
Comparative transcriptomic analysis to identify overlapping gene expression patterns.

Main Results:

EoE showed significantly higher gene expression overlap with AD (10%) than with AA (7%).
Eighteen genes, including filaggrin and histamine receptor H1, were commonly dysregulated across all three diseases.
IL-13 pathway involvement was greater in EoE (22% overlap) compared to AD (9%) and AA (5%).

Conclusions:

EoE, AD, and AA share common molecular underpinnings, suggesting a unified etiology.
A closer molecular relationship exists between EoE and AD, especially concerning IL-13 pathways.
Findings support the development of shared therapeutic strategies for these interconnected atopic diseases.