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MouseBytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment.

Flavio H Beraldo1,2,3, Daniel Palmer1,4, Sara Memar1

  • 1Robarts Research Institute, The University of Western Ontario, Ontario, Canada.

Elife
|December 12, 2019
PubMed
Summary

Open Science principles are advanced for rodent cognitive studies by integrating touchscreen testing with open-access data repositories and knowledge platforms. This enhances data sharing and reproducibility in Alzheimer's disease research.

Keywords:
Alzheimer's diseaseamyloid-beta plaquescognitionhigh-throughput screeningmouseneuroscienceopen-access databasetouchscreen

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Open Science

Background:

  • Open Science practices promote data sharing and reproducibility in research.
  • Limited tools exist for sharing rodent cognitive study data.
  • Automated touchscreen tests offer standardized cognitive assessment outputs.

Purpose of the Study:

  • To integrate touchscreen cognitive testing with open-access data repositories and knowledge dissemination platforms.
  • To create resources for sharing protocols and data in rodent cognitive research.
  • To expand knowledge on age-dependent cognitive deficits in Alzheimer's disease mouse models.

Main Methods:

  • Integration of automated touchscreen cognitive testing with the open-access database mousebytes.ca.
  • Development of a Web platform (touchscreencognition.org) for knowledge dissemination.
  • Generation of a large dataset of age-dependent cognitive assessments in mouse models of Alzheimer's disease.

Main Results:

  • Established integrated platforms for sharing and disseminating rodent cognitive data.
  • Compiled the largest dataset to date on age-dependent cognitive assessment in Alzheimer's disease mouse models.
  • Identified affected cognitive domains in male and female mice across three strains.

Conclusions:

  • The new platforms enhance protocol sharing, data availability, and transparency in rodent cognitive research.
  • Facilitates meta-analysis and reuse of mouse cognitive data to improve replicability and reproducibility.
  • Promotes Open Science principles within the field of rodent cognitive neuroscience.