Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Comparative studies on interaction between theophylline and quinolones.

K Takagi1, T Hasegawa, Y Ogura

  • 1Second Department of Internal Medicine, Nagoya University School of Medicine, Japan.

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
|January 1, 1988
PubMed
Summary

This study compared the drug interactions of theophylline with T-3262 and enoxacin. T-3262 showed a smaller increase in theophylline plasma concentration than enoxacin, indicating a less significant drug interaction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relaxant effect of C-type natriuretic peptide on guinea-pig tracheal smooth muscle.

Arzneimittel-Forschung·1992
Same author

Selective bronchodilators from 1-(5'-oxohexyl)xanthines.

The Journal of pharmacy and pharmacology·1992
Same author

Effects of enforced exercise on biomechanical properties of the anterior cruciate ligament of bipedal rats.

Nihon Seikeigeka Gakkai zasshi·1992
Same author

[In vitro susceptibilities of Mycobacterium avium and Mycobacterium intracellulare to new macrolides, new quinolones, and antituberculous drugs on Dubos agar medium].

Kekkaku : [Tuberculosis]·1992
Same author

[Upper gastrointestinal bleeding in the elderly].

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·1992
Same author

Effects of alkyl substitutions of xanthine skeleton on bronchodilation.

Journal of medicinal chemistry·1992

Area of Science:

  • Pharmacology
  • Drug Metabolism
  • Clinical Pharmacology

Background:

  • Theophylline is a widely used medication with a narrow therapeutic index.
  • Quinolone antibiotics can interact with theophylline, potentially leading to adverse effects.
  • Understanding drug interactions is crucial for patient safety and effective treatment.

Purpose of the Study:

  • To compare the pharmacokinetic and metabolic interactions between theophylline and a new quinolone, T-3262.
  • To evaluate T-3262's interaction potential relative to enoxacin, a known theophylline interaction drug.

Main Methods:

  • A comparative pharmacokinetic study was conducted in healthy male volunteers.
  • Theophylline was administered alone and with T-3262 or enoxacin under steady-state conditions.

Related Experiment Videos

  • Plasma and urine concentrations of theophylline and its metabolites were measured using high-performance liquid chromatography.

    • Main Results:

    • Coadministration with T-3262 and enoxacin significantly increased plasma theophylline concentrations by 1.5-fold and threefold, respectively.
    • Total body clearance of theophylline decreased significantly with both T-3262 (34%) and enoxacin (63%).
    • Urinary theophylline increased and 3-methylxanthine decreased, suggesting inhibition of the 1-demethylation pathway.

    Conclusions:

    • T-3262 exhibits a less pronounced interaction with theophylline compared to enoxacin.
    • The interaction likely involves the inhibition of theophylline's 1-demethylation metabolic pathway by quinolones.
    • These findings are important for predicting and managing potential drug interactions with T-3262.